PedAM

Pediatric Disease Annotations & Medicines


	crimean-congo hemorrhagic fever

Disease ID	95
Disease	crimean-congo hemorrhagic fever
Definition	A severe, often fatal disease in humans caused by the Crimean-Congo hemorrhagic fever virus (HEMORRHAGIC FEVER VIRUS, CRIMEAN-CONGO).
Synonym	cchf cchf - crimean-congo haemorrhagic fever cchf - crimean-congo hemorrhagic fever central asian haemorrhagic fever central asian hemorrhagic fever chf - crimean haemorrhagic fever chf - crimean hemorrhagic fever chf congo virus congo fever congo virus infect congo virus infection congo virus infections congo-crimean haemorrhagic fever congo-crimean hemorrhagic fever congo-crimean hemorrhagic fever (disorder) crimean congo haemorrhagic fever crimean congo hemorrhagic fever crimean haemorrhagic fever crimean hemorrhagic fev crimean hemorrhagic fever crimean hemorrhagic fever [chf congo virus] crimean hemorrhagic fevers crimean-congo haemorrhagic fever fever, crimean hemorrhagic fevers, crimean hemorrhagic hemorrhagic fever, crimean hemorrhagic fever, crimean [disease/finding] hemorrhagic fever, crimean-congo hemorrhagic fevers, crimean infect congo virus infection, congo virus infections, congo virus viral haemorrhagic fever, crimean-congo viral hemorrhagic fever, crimean-congo
Orphanet	ORPHANET:99827
DOID	DOID:12287
ICD10	ICD10CM:A98.0
UMLS	C0019099
MeSH	D006479
SNOMED-CT	SNOMEDCT_US_2016_09_01:43489008
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:4) C0040034 \| thrombocytopenia \| 2 C0001339 \| acute pancreatitis \| 1 C0022116 \| ischemia \| 1 C0003864 \| arthritis \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:2) 51311 \| TLR8 \| infer 54106 \| TLR9 \| infer
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:57) 10942 \| PRSS21 \| DISEASES 8756 \| ADAM7 \| DISEASES 1361 \| CPB2 \| DISEASES 9567 \| GTPBP1 \| DISEASES 51311 \| TLR8 \| DISEASES 56729 \| RETN \| DISEASES 4790 \| NFKB1 \| DISEASES 54210 \| TREM1 \| DISEASES 4738 \| NEDD8 \| DISEASES 80326 \| WNT10A \| DISEASES 3569 \| IL6 \| DISEASES 3442 \| IFNA5 \| DISEASES 7305 \| TYROBP \| DISEASES 6929 \| TCF3 \| DISEASES 60482 \| SLC5A7 \| DISEASES 3383 \| ICAM1 \| DISEASES 4437 \| MSH3 \| DISEASES 2028 \| ENPEP \| DISEASES 5286 \| PIK3C2A \| DISEASES 3454 \| IFNAR1 \| DISEASES 3578 \| IL9 \| DISEASES 4841 \| NONO \| DISEASES 3934 \| LCN2 \| DISEASES 2321 \| FLT1 \| DISEASES 267 \| AMFR \| DISEASES 1973 \| EIF4A1 \| DISEASES 4880 \| NPPC \| DISEASES 1673 \| DEFB4A \| DISEASES 3627 \| CXCL10 \| DISEASES 2147 \| F2 \| DISEASES 30835 \| CD209 \| DISEASES 2193 \| FARSA \| DISEASES 1974 \| EIF4A2 \| DISEASES 55742 \| PARVA \| DISEASES 2152 \| F3 \| DISEASES 1981 \| EIF4G1 \| DISEASES 8720 \| MBTPS1 \| DISEASES 3767 \| KCNJ11 \| DISEASES 80274 \| SCUBE1 \| DISEASES 462 \| SERPINC1 \| DISEASES 1629 \| DBT \| DISEASES 959 \| CD40LG \| DISEASES 252995 \| FNDC5 \| DISEASES 1906 \| EDN1 \| DISEASES 9636 \| ISG15 \| DISEASES 3446 \| IFNA10 \| DISEASES 2813 \| GP2 \| DISEASES 55504 \| TNFRSF19 \| DISEASES 55576 \| STAB2 \| DISEASES 3112 \| HLA-DOB \| DISEASES 199800 \| ADM5 \| DISEASES 50863 \| NTM \| DISEASES 7124 \| TNF \| DISEASES 3451 \| IFNA17 \| DISEASES 3586 \| IL10 \| DISEASES 1977 \| EIF4E \| DISEASES 11201 \| POLI \| DISEASES
Locus	(Waiting for update.)

Disease ID	95
Disease	crimean-congo hemorrhagic fever
Integrated Phenotype	HPO \| Name(Total Integrated Phenotypes:23) HP:0012735 \| Cough HP:0002239 \| Gastrointestinal hemorrhage HP:0001882 \| Leukopenia HP:0000988 \| Skin rash HP:0000952 \| Jaundice HP:0002014 \| Diarrhea HP:0006543 \| Cardiorespiratory arrest HP:0003326 \| Myalgia HP:0001945 \| Fever HP:0002315 \| Headache HP:0001892 \| Abnormal bleeding HP:0000967 \| Petechiae HP:0100776 \| Recurrent pharyngitis HP:0100749 \| Chest pain HP:0002910 \| Elevated hepatic transaminases HP:0001873 \| Thrombocytopenia HP:0001397 \| Hepatic steatosis HP:0012378 \| Fatigue HP:0000421 \| Epistaxis HP:0000554 \| Uveitis HP:0002017 \| Nausea and vomiting HP:0002027 \| Abdominal pain HP:0000225 \| Gingival bleeding
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:8) HP:0001662 \| Bradycardia \| 2 HP:0001873 \| Low platelet count \| 2 HP:0002904 \| High blood bilirubin levels \| 1 HP:0001369 \| Arthritis \| 1 HP:0001735 \| Acute pancreatitis \| 1 HP:0003281 \| Increased ferritin \| 1 HP:0003256 \| Coagulopathy \| 1 HP:0012156 \| Hemophagocytosis \| 1

Disease ID	95
Disease	crimean-congo hemorrhagic fever
Manually Symptom	UMLS \| Name(Total Manually Symptoms:1) C0019080 \| hemorrhage
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:2)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs179008	25879168	51284	TLR7	umls:C0019099	BeFree	Toll-like receptor 7 Gln11Leu, c.4-151A/G, and +1817G/T polymorphisms in Crimean Congo hemorrhagic fever.	0.000271442	2015	TLR7	X	12885540	A	C,T
rs386547285	20674764	54106	TLR9	umls:C0019099	BeFree	Our findings suggest that TLR8 Met1Val, TLR8 -129C/G, and TLR9 -1486T/C polymorphisms are important on clinical course of CCHF disease.	0.002638474	2010	NA	NA	NA	NA	NA

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0001645	Sudden cardiac death	MP:0003393	decreased cardiac output;HP:0004370	Abnormality of temperature regulation

Mapped by homologous gene(Total Items:1)
HP ID	HP Name	MP ID	MP Name	Annotation
HP:0100776	Recurrent pharyngitis	MP:0005463	abnormal CD4-positive, alpha-beta T cell physiology;HP:0001645	Sudden cardiac death

Chemical(Total Drugs:1)
CUI	ChemicalName	ChemicalID	CasRN	DiseaseName	DiseaseID	DirectEvidence	PubMedIDs
C0019099	ribavirin	D012254	36791-04-5	hemorrhagic fever, crimean	MESH:D006479	therapeutic	2546248

FDA approved drug and dosage information(Total Drugs:0)
(Waiting for update.)

FDA labeling changes(Total Drugs:0)
(Waiting for update.)

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